WebFeb 8, 2024 · The British Journal of Anaesthesia (BJA) publishes high-impact original work in all branches of anaesthesia, critical care medicine, pain medicine and perioperative medicine including fundamental, … WebFeb 8, 2024 · Metabolic alkalosis and mixed acid–base disturbance in anaesthesia and critical care. M. Park, D. Sidebotham. Published online: February 22, 2024. p128-135. …
Ketamine: an old drug revitalized in pain medicine BJA Education ...
Webopioid), medication concentrations, and infusion settings Fig 1 Decision to place catheter intrathecal or resite epidurally after accidental dural puncture. The figure depicts multiple factors that may favour or not favour placing an ITC after accidental dural puncture. Management of intrathecal catheters BJA Education-Volume 20, Number 7 ... WebMorphine, a hydrophilic opioid, is commonly used in thoracotomy. It traverses the dura slowly, binds little to epidural fat, and entry to the systemic circulation is delayed. Morphine thus remains in relatively large concentrations in the CSF resulting in an onset of action within 1–2 h of administration and lasting up to 24 h. orchester night of the proms
Intrathecal opioid analgesia
WebAug 1, 2004 · Opioids can be added to LA or used as a sole epidural or intrathecal agent to provide analgesia for labour . Neuraxial opioids have been associated with pruritus, nausea and vomiting, hypotension, urinary retention, uterine hyperstimulation, fetal bradycardia and maternal respiratory depression. ... About BJA Education; Online ISSN … Intrathecal opioids have been demonstrated to provide effective analgesia in the postoperative period. The principal advantage of intrathecal over systemic opioid techniques is that the former produces ‘segmental analgesia’ resulting in localized nociception without motor, sensory, autonomic, or systemic side … See more Intrathecal opioids bind to a family of G-protein-linked pre- and postsynaptic opioid receptors in Laminae I and II of the dorsal horn. Receptor … See more The pharmacokinetics of intrathecal opioids are complex, follow a multi-compartmental model (Fig. 1), and are determined by the … See more The physicochemical properties of intrathecal opioids determine their onset time, duration of action, and potency. High lipid solubility and low pKa results in a highly potent opioid with a rapid onset of effect, but limited … See more Side-effects are mediated by opioid receptors. Segmental analgesia after intrathecal opioids administration should confer a lower side-effect profile compared with systemic opioids administration. A recent prospective … See more WebSep 24, 2014 · Nearly one-third of patients experience moderate-to-severe postoperative pain after day surgery. Standardized pain evaluation, protocols, and multi-modal analgesia are key to effective pain management. Patient education and preparation will improve patient compliance of analgesia. Alternatives to opioids should be promoted in day … orchester oper frankfurt