WebOriginal Article In vivo overexpression of frataxin causes toxicity mediated by iron-sulfur cluster deficiency Claudia Huichalaf, 1Tyler L. Perfitt,1 Anna Kuperman,1 Renea Gooch, Ramesh C. Kovi,2 Karrie A. Brenneman,2 Xian Chen, 3Dinesh Hirenallur-Shanthappa, Tiffany Ma,1 Basel T. Assaf, 2Ingrid Pardo,2 Tania Franks, Laura Monarski,2 Ting-Wen … Web2 days ago · Mutations in the ABCB4 gene lead to a wide-spectrum of rare liver diseases including progressive familial intrahepatic cholestasis type 3 (PFIC3) and low-phospholipid associated cholelithiasis (LPAC) syndrome. PFIC3 patients develop symptoms during late infancy, including severe itching, jaundice, and failure to thrive. The condition may …
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In vivo overexpression of frataxin causes toxicity mediated by …
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