WebMar 16, 2008 · In addition, IRF1 regulates the induction of inducible nitric oxide synthase and the interleukin 12 p35 subunit (IL-12p35) in macrophages and has been linked to the pathogenesis of autoimmune ... WebOct 29, 2015 · IRF1 is a critical transcription factor for iNOS induction and is antagonized by IRF2. In the stimulated macrophages, IRF1 accumulated in the nucleus without degradation by 5AZ treatment. In...
Investigation of oncolytic effect of recombinant Newcastle …
WebMay 4, 2024 · The miR-19a-3p/STAT1/IRF1 pathway can potentially be used to design novel immunotherapy for modulating macrophage polarization. Introduction Macrophages, an essential component of innate immunity, have high plasticity and can display divergent phenotypes and functions ( Lawrence and Natoli, 2011 ). WebIn murine RAW 264.7 macrophages, the essential role of the IRF-1 binding site (positions −913 to −923 bp) for induction of the murine iNOS promoter has been demonstrated. Mutations of this binding site blocked the IFN-γ-mediated enhancement of LPS-induced iNOS promoter activity in macrophages ( Martin et al., 1994; Spink and Evans, 1997 ). crystal research and technology期刊缩写
The macrophage IRF8/IRF1 regulome is required for protection against
WebAug 9, 2024 · Macrophages are immune sentinels essential for pathogen recognition and immune defense. Nucleic acid-sensing toll-like receptors like TLR7 activate tailored proinflammatory and interferon responses in macrophages. Here we found that TLR7 activation constrained itself and other TLRs from inducing interferon response genes in … WebJul 8, 2024 · One strategy used colony-stimulating factor 1 receptor (CSF1R) inhibition to block glioma progression by reducing macrophage M2 polarization ( 15 ), but acquired resistance was observed in animal model experiments ( 16) and limited efficacy was found in clinical trials ( 17 ). WebAug 27, 2024 · Polarized macrophages can be broadly classified into classically activated macrophages (M1) and alternatively activated macrophages (M2) in response to the microenvironment signals. Interferon regulatory factor 1 (IRF1) has been demonstrated to play a critical role in macrophage polarization. crystal research and technology版面费